On?POM Ring?Opening Polymerisation of <i>N</i> ?Carboxyanhydrides
نویسندگان
چکیده
The ring-opening polymerisation of ?-amino acid N-carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted narrow molecular weight distributions. Here we show how polyoxometalates (POMs)—redox-active metal-oxide anions—can serve as inorganic scaffold initiators for such NCA polymerisations. This “On-POM polymerisation” strategy serves an innovative platform design hybrid materials additive or synergistic properties stemming from the polypeptide component parts. We have used this synthetic approach synthesise library bactericidal poly(lysine)–POM derivatives that can be prevent biofilm formation. versatile method provides flexible combining scaffolds amino acids, potential tailor improve specificity performance antimicrobial materials.
منابع مشابه
Primary ammonium/tertiary amine-mediated controlled ring opening polymerisation of amino acid N-carboxyanhydrides.
Stable commercial primary ammonium chlorides were combined with tertiary amines to initiate the controlled ring opening polymerisation of amino acid N-carboxyanhydrides to yield polypeptides with defined end group structure, predetermined molar mass and narrow molar mass distribution.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/anie.202013563