On?POM Ring?Opening Polymerisation of <i>N</i> ?Carboxyanhydrides

نویسندگان

چکیده

The ring-opening polymerisation of ?-amino acid N-carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted narrow molecular weight distributions. Here we show how polyoxometalates (POMs)—redox-active metal-oxide anions—can serve as inorganic scaffold initiators for such NCA polymerisations. This “On-POM polymerisation” strategy serves an innovative platform design hybrid materials additive or synergistic properties stemming from the polypeptide component parts. We have used this synthetic approach synthesise library bactericidal poly(lysine)–POM derivatives that can be prevent biofilm formation. versatile method provides flexible combining scaffolds amino acids, potential tailor improve specificity performance antimicrobial materials.

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ژورنال

عنوان ژورنال: Angewandte Chemie

سال: 2021

ISSN: ['1521-3773', '1433-7851', '0570-0833']

DOI: https://doi.org/10.1002/anie.202013563